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Render Timestamp: 2024-12-23T12:09:14.816Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:15:24.219
Product last modified at: 2024-12-17T18:49:08.197Z
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PDP - Template Name: Chemical Modulators
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Dexamethasone #14776

    Product Information

    Product Usage Information

    Dexamethasone is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1.27 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1,000 nM for 1-24 hr.

    Storage

    Store lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 392.5 g/mol
    Purity >98%
    Molecular Formula C22H29FO5
    CAS 50-02-2
    Solubility Soluble in DMSO at 40mg/ml.

    Background

    Dexamethasone is a synthetic glucocorticoid that binds to the human glucocorticoid receptor (GR). Treatment of cells with dexamethasone leads to nuclear translocation and activation of GR. This elicits anti-inflammatory, cellular proliferation, and metabolic responses via GR-mediated transcriptional activation or repression of target genes (1-4). Research studies show that dexamethasone inhibits dendritic cell differentiation and maturation (5). The inhibition of nitric oxide synthase by dexamethasone has also been observed (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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