4EHP (D54C2) Rabbit mAb #6916
Inquiry Info. # 6916
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Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
A mammalian cap-binding protein related to eIF4E, 4E Homologous Protein (4EHP), was later identified (6). 4EHP does not interact with eIF4G and therefore cannot activate translation (7). Instead, it inhibits the translation of a subset of mRNAs (7).
- Sonenberg, N. et al. (1978) Proc. Natl. Acad. Sci. USA 75, 4843-47.
- Gingras, A.C. et al. (1999) Annu. Rev. Biochem. 68, 913-63.
- Waskiewicz, A. et al. (1999) Mol. Cell. Biol. 19, 1871-80.
- Pyronnet, S. et al. (1999) EMBO J. 18, 270-9.
- Raught, B. et al. (2000) EMBO J. 19, 434-44.
- Rom, E. et al. (1998) J Biol Chem 273, 13104-9.
- Zuberek, J. et al. (2007) RNA 13, 691-7.
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