The Jak/Stat Utilization Table tabulates the combinatorial use of tyrosine kinases and Stat proteins in cytokine/growth factor signaling.
| Ligand | Receptor | Jak-kinase | Other Tyrosine Kinases | Stat Family Members |
|---|---|---|---|---|
| IL-6 | IL-6Ra+gp130 | Jak1,2, Tyk2 | Hck | Stat1, Stat3 |
| IL-11 | IL-11R+gp130 | Jak1,2, Tyk2 | Src, Yes | Stat3 |
| CNTF, CT-1, LIF, OSM | CNTFR+gp130, CT-1R+gp130, LIFR+gp130, OSMR+gp130 | Jak1,2, Tyk2 | Src family | Predominant: Stat3 Secondary: Stat1,5 |
| G-CSF | G-CSFR | Jak2, Tyk2 | Lyn | Stat3 |
| IL-12 (p40+p35) | IL-12Rβ1+IL-12Rβ2 | Jak2, Tyk2 | Lck | Stat4 |
| Leptin | LeptinR | Jak2 | not determined | Stat3,5,6 |
| IL-3 | IL-3Rα+βc | Jak2 | Fyn, Hck, Lyn | Stat3,5,6 |
| IL-5 | IL-5R+βc | Jak2 | Btk | Stat3,5,6 |
| GM-CSF | GM-CSFR+βc | Jak2 | Hck, Lyn | Stat3,5 |
| Angiotensin | GPCR | Jak2, Tyk2 | Stat1,2,3 | |
| Serotonin | GPCR | Jak2 | Stat3 | |
| α-Thrombin | GPCR | Jak2 | Stat1,3 | |
| Chemokines | CXCR4 | Jak2,3 | ||
| IL-2 | IL-2Rα+IL-2Rb+γc | Jak1,2,3 | Fyn, Hck, Lck, Syk, Tec | Stat3,5 |
| IL-4 | IL-4Rα+γcR or IL-4Rα+IL-13Rα1 | Jak1,3 | Lck, Tec | Stat6 |
| IL-7 | IL-7R+γc | Jak1,3 | Lyn | Stat3,5 |
| IL-9 | IL-9R+γc | Jak1,3 | not determined | Stat1,3,5 |
| IL-13 | IL-13Rα1+ IL-4Rα | Jak1,2, Tyk2 | Ctk | Stat6 |
| IL-15 | IL-15Rα+IL-2Rβ+γc | Jak1,3 | Lck | Stat3,5 |
| IL-19 | IL-20Rα+IL-20Rβ | Jak1, ? | Stat3 | |
| IL-20 | IL-20Rα+IL-20Rβ, IL-22R+IL-20Rβ | Jak1, ? | Stat3 | |
| IL-21 | IL-21R+γc | Jak1,3 | Stat1,3,5 | |
| IL-22 | IL-22R+IL-10Rβ | Jak1, Tyk2 | Stat1,3,5 | |
| IL-23 (p40+p19) | IL-12Rβ1+IL-23R | Jak2 | Tyk2 | Stat4 |
| IL-24 | same as IL-20 | Jak1, ? | Stat3 | |
| IL-26 | IL-20Rα+IL-10Rβ | Jak1, Tyk2 | Stat3 | |
| IL-27 (EBI3+p28) | gp130+WSX1 | Jak1,2, Tyk2 | Stat1,2,3,4,5 | |
| IL-28A, IL-28B, IL-29 | IL-28R+IL-10Rβ | Jak1, Tyk2 | Stat1,2,3,4,5 | |
| IL-31 | IL-31Rα+OSMR | Jak1,2, Tyk2 | Stat1,3,5 | |
| IL-35 (p35+EBI3) | gp130+WSX1 | Jak1,2, Tyk2 | Stat1,3,5 | |
| GH | GHR | Jak2 | Src family | Stat3,5 (mainly Stat5a) |
| Tpo | TpoR (c-Mpl) | Jak2, Tyk2 | Lyn | Stat1,3,5 |
| Epo, Pro | EpoR, ProlactinR | Jak2 | Src Family | Stat5 (mainly Stat5a) |
| Interferon (IFNα/β) | IFNAR1+IFNAR2 | Jak1, Tyk2 | Lck | Predominant: Stat1,2 Secondary: Stat3,4,5,6 |
| IFN-γ | IFN-gR1+IFN-γR2 | Jak1, Jak2 | Hck, Lyn | Stat1 |
| IL-10 | IL-10Rα+ IL-10Rβ | Jak1, Tyk2 | not determined | Stat1,3,5 |
| TLSP | TLSPR and IL-7R | Jak1, possibly Jak2 | not determined | Stat3,5 |
| EGF | EGFR | Jak1 | EGFR, Src | Stat1,3,5 |
| PDGF | PDGFR | Jak1,2 | PDGFR, Src | Stat1,3,5 |
CST would like to thank Prof. Stefan N. Constantinescu, Ludwig Institute for Cancer Research, Brussels, Belgium, for contributing to this table.
created October 2008
revised April 2013
