Revision 3
#50646
Store at -20C
5-Azacytidine
50 mg
877-616-CELL (2355)
877-678-TECH (8324)
3 Trask Lane | Danvers | Massachusetts | 01923 | USA
For Research Use Only. Not for Use in Diagnostic Procedures.
Background
5-Azacytidine is a nucleoside analogue of cytidine and a DNA methyltransferase inhibitor. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases, which contributes to reversing DNA methylation (1). It also functions in reducing DNA hypermethylation in certain diseases, including myelodysplastic syndrome (MDS) (2).
Molecular Formula
C8H12N4O5
Molecular Weight
244.2 g/mol
Purity
>98%
CAS
320-67-2
Solubility
Soluble in DMSO at 25 mg/mL or water at 12 mg/mL.
Storage
Directions for Use
5-Azacytidine is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.37 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Wear personal protective equipment. Do not empty product into drains. Do not handle until all safety precautions have been read and understood.
Safety Information: 5-Azacytidine has been classified by the International Agency for Research on Cancer (IARC) as a probable human carcinogen (Group 2A). It is suspected of causing genetic defects. It may cause adverse reproductive effects - such as birth defect, miscarriages, or infertility. Avoid contact during pregnancy and while nursing. If exposed or concerned, get medical advice. See Safety Data Sheet (SDS).
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Cross-Reactivity Key
H: Human M: Mouse R: Rat Hm: Hamster Mk: Monkey Vir: Virus Mi: Mink C: Chicken Dm: D. melanogaster X: Xenopus Z: Zebrafish B: Bovine Dg: Dog Pg: Pig Sc: S. cerevisiae Ce: C. elegans Hr: Horse GP: Guinea Pig Rab: Rabbit G: Goat All: All Species Expected
Trademarks and Patents
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Limited Uses
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