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Render Timestamp: 2024-09-27T09:58:51.974Z
Commit: 53da7bbf777da8a463c431a64421017667e9ff1d
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

PPARgamma Antibody #2492

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Inquiry Info. # 2492

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    Supporting Data

    REACTIVITY
    SENSITIVITY
    MW (kDa) 55
    SOURCE Rabbit

    Product Information

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Specificity / Sensitivity

    PPARgamma Antibody detects endogenous levelss of total PPARgamma protein. The antibody does not cross-react with PPARalpha or PPARdelta.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser84 of human PPARgamma. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the ligand-activated nuclear receptor superfamily and functions as a transcriptional activator (1). PPARγ is preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage (2). Besides its role in mediating adipogenesis and lipid metabolism (2), PPARγ also modulates insulin sensitivity, cell proliferation and inflammation (3). PPARγ transcriptional activity is inhibited by MAP kinase phosphorylation of PPARγ at Ser84 (4,5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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