| Product Includes | Product # | Quantity | Isotype/Source |
|---|---|---|---|
| Neurogranin (E9L8D) Rabbit mAb (BSA and Azide Free) | 85207 | 100 µg | Rabbit IgG |
| Neurogranin (E9V5C) Rabbit mAb (BSA and Azide Free) | 20149 | 100 µg | Rabbit IgG |
Description
The Total Neurogranin Matched Antibody Pair is ideal for use with immunoassay technologies and high-throughput ELISA platforms requiring antibody pairs with specialized or custom antibody labeling. Labels include fluorophores, lanthanides, biotin, and beads. Platforms requiring conjugated Matched Antibody Pairs include MSD, Quanterix Simoa, Alpha Technology (AlphaScreen, AlphaLISA, LANCE, HTRF), and Luminex.
Learn how Matched Antibody Pairs move your projects forward, faster at cst-science.com/matched-antibody-pairs.
Specificity/Sensitivity
Storage
Directions for Use
Formulation
Background
Neurogranin is a small neuronal protein that binds to calmodulin in the absence of Ca2+ (1,2). Calmodulin binds Ca2+ and acts as a Ca2+ sensor to drive Ca2+-dependent signal transduction pathways by modulating its interaction with various kinases and phosphatases (3). In the postsynaptic compartment of the neuron, Ca2+ is carefully regulated and is a critical regulator of synaptic function and plasticity (4). Neurogranin is primarily expressed in the brain and is enriched in somato-dendritic compartments of projection neurons in various regions of the brain (5). Postsynaptically-enriched neurogranin likely influences Ca2+ or Ca2+/calmodulin-dependent neuronal functions, including synaptic plasticity, by binding to and releasing calmodulin in a Ca2+-dependent manner (6-9). Genetic variants in the gene encoding neurogranin, NRGN, are linked to several neuropsychiatric diseases, including schizophrenia (10). Interestingly, increase in cerebrospinal fluid neurogranin is correlated with neurodegenerative disease progression, which suggests that neurogranin could act as a biomarker for diseases like Alzheimer’s disease (11).
- Baudier, J. et al. (1991) J Biol Chem 266, 229-37.
- Gispen, W.H. et al. (1991) Mol Neurobiol 5, 61-85.
- Chin, D. and Means, A.R. (2000) Trends Cell Biol 10, 322-8.
- Blackstone, C. and Sheng, M. (2002) Front Biosci 7, d872-85.
- Gerendasy, D.D. and Sutcliffe, J.G. (1997) Mol Neurobiol 15, 131-63.
- Huang, K.P. et al. (2004) J Neurosci 24, 10660-9.
- Pak, J.H. et al. (2000) Proc Natl Acad Sci USA 97, 11232-7.
- Zhong, L. et al. (2009) EMBO J 28, 3027-39.
- Jones, K.J. et al. (2018) Proc Natl Acad Sci USA 115, E5805-E5814.
- Jin, L. et al. (2019) Medicine (Baltimore) 98, e18518.
- Willemse, E.A.J. et al. (2018) Clin Chem 64, 927-37.
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
Limited Uses
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