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Product last modified at: 2024-12-20T19:30:08.767Z
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PDP - Template Name: Assay Kit One Column
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Senescence β-Galactosidase Staining Kit #9860

    Product Information

    Protocol

    Product Description

    The Senescence β-Galactosidase Staining Kit is designed to conveniently provide reagents needed to detect β-galactosidase activity at pH 6, a known characteristic of senescent cells. Papers have published using this kit in both cells and frozen tissue. The kit includes all reagents necessary for this assay.

    Background

    Limited capacity to replicate is a defining characteristic of most normal cells and culminates in senescence, an arrested state in which the cell remains viable (1). Senescent cells are not stimulated to divide by serum or passage in culture, and senescence invokes a specific cell cycle profile that differs from most damage-induced arrest processes or contact inhibition (2). An enlarged cell size, expression of pH-dependent β-galactosidase activity (3), and an altered pattern of gene expression (4,5) further characterize senescent cells.
    For Research Use Only. Not For Use In Diagnostic Procedures.
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