Everolimus #12017
Product Information
Product Usage Information
Everolimus is supplied as a lyophilized powder. For a 1 mM stock, reconstitute the 1 mg in 1.04 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-100 nM either as a pretreatment for 0.5-1 hr prior to treating with a stimulator or is used alone with varying treatment times lasting up to 24 hr. Soluble in DMSO or ethanol at 100 mg/ml; very poorly soluble in water with maximum solubility ~1-10 µM.
Storage
Product Description
| Molecular Weight | 958.22 g/mol |
| Purity | >99% |
| Molecular Formula | C53H83NO14 |
| CAS | 159351-69-6 |
| Solubility | Soluble in DMSO and EtOH at 100mg/ml. |
Background
- Sedrani, R. et al. (1998) Transplant Proc 30, 2192-4.
- Schuler, W. et al. (1997) Transplantation 64, 36-42.
- Houghton, P.J. (2010) Clin Cancer Res 16, 1368-72.
- Rosich, L. et al. (2012) Clin Cancer Res 18, 5278-89.
- Cao, C. et al. (2006) Cancer Res 66, 10040-7.
- Lane, H.A. et al. (2009) Clin Cancer Res 15, 1612-22.
- Knaup, K.X. et al. (2009) Mol Cancer Res 7, 88-98.
Limited Uses
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