Render Target: STATIC
Render Timestamp: 2024-12-26T11:26:29.010Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-19 21:57:43.620
Product last modified at: 2024-12-17T19:02:43.244Z
Cell Signaling Technology Logo
1% for the planet logo
PDP - Template Name: Chemical Modulators
PDP - Template ID: *******c501c72

Hydroxychloroquine Sulfate #85523

    Product Information

    Product Usage Information

    Hydroxychloroquine Sulfate is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.15 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 434 g/mol
    Purity >98%
    Molecular Formula C18H26ClN3O • H2SO4
    CAS 747-36-4
    Solubility Soluble in water at 40 mg/ml.

    Background

    Hydroxychloroquine Sulfate is a 4-aminoquinoline derivative of quinine known to sensitize cells to apoptosis (1,2). This small compound is an anti-malaria drug that has been found to be an effective treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and other rheumatic diseases (3). Current studies exhibit the diverse immunomodulatory effects that Hydroxychloroquine Sulfate can span, including metabolic, cardiovascular, antithrombotic, antineoplastic, and anti-infectious agent modulation. Prospective modes of action include inhibition of lysosome and autophagosome functions, subsequent immune activation, and interference of cytokine production via its ability to inhibit TLR binding and processing (4). Studies have shown that Hydroxychloroquine Sulfate inhibits IFN-β production (IC50 = 25 μM) by disrupting the cGAS/dsDNA complex (5). Hydroxychloroquine Sulfate can inhibit SARS-CoV-2 infection in vitro and the antiviral and anti-inflammatory effects of this compound make it important when studying different viral diseases (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.