PD 0325901 #79241

Name: PD 0325901
Price: 136.00 USD
Availability: InStock

Product Information

Product Usage Information

PD 0325901 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.03 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	482.2 g/mol
Purity	>98%
Molecular Formula	C₁₆H₁₄F₃IN₂O₄
CAS	391210-10-9
Solubility	Soluble in DMSO at 12 mg/ml.

Background

PD 0325901 is a potent and selective non-ATP competitive MEK inhibitor. This small molecule is highly effective at inhibiting cell growth and proliferation in various cancer cells (1). The potency of PD 0325901 has been illustrated by the inhibition of ERK phosphorylation in mouse and human cell models with an IC₅₀ of 0.33 nM and between 20-50 nM, respectively (1,2). PD 0325901 increases the self-renewal of mouse embryonic stem cells (mESCs) by enhancing the expression of pluripotency genes and acts as an antagonist for retinoic acid (RA) induced cell differentiation (3).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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