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Render Timestamp: 2024-12-26T11:13:43.470Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:22:48.255
Product last modified at: 2024-12-17T18:58:23.985Z
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PDP - Template Name: Protein Control
PDP - Template ID: *******0d5b8ff
  1. Products /
  2. Recombinant Proteins /
  3. SARS-CoV-2 Spike S1-NTD (16-316) Recombinant Protein (mFc-Tag)

SARS-CoV-2 Spike S1-NTD (16-316) Recombinant Protein (mFc-Tag) #61516

    Supporting Data

    MW (kDa) 220 (non-reduced); 95 (reduced)

    Product Information

    Formulation

    Expression Host: Human (HEK293 cells)
    Supplied in a PBS solution (pH 7.2).

    Storage

    Stable at -80°C for 3 years after receipt. Avoid repeated freeze-thaw cycles.

    Product Description

    SARS-CoV-2 Spike S1-NTD (16-316) Recombinant Protein (mFc-Tag) is derived from a recombinant expression construct corresponding to the amino terminal domain (NTD) of the S1 fragment of SARS-CoV-2 spike protein. The expressed protein contains a murine Fc-Tag at its carboxy terminus.
    MW (kDa) 220 (non-reduced); 95 (reduced)
    Purity 87%, determined by SDS-PAGE.

    Background

    The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is similar to other coronaviruses, and is comprised of four key structural proteins: S, the spike protein, E, the envelope protein, M, the membrane protein, and N, the nucleocapsid protein (2). Coronavirus spike proteins are class I fusion proteins and harbor an ectodomain, a transmembrane domain, and an intracellular tail (3,4). The highly glycosylated ectodomain projects from the viral envelope surface and facilitates attachment and fusion with the host cell plasma membrane. The ectodomain can be further subdivided into host receptor-binding domain (RBD) (S1) and membrane-fusion (S2) subunits, which are produced upon proteolysis by host proteases at S1/S2 and S2’ sites. S1 and S2 subunits remain associated after cleavage and assemble into crown-like homotrimers (2,4). In humans, both SARS-CoV and SARS-CoV-2 spike proteins utilize the angiotensin-converting enzyme 2 (ACE2) protein as a receptor for cellular entry (5-7). Spike protein subunits represent a key antigenic feature of coronavirus virions, and therefore represent an important target of vaccines, novel therapeutic antibodies, and small-molecule inhibitors (8,9).

    Database Links

    UniProt ID: P0DTC2


    Entrez-Gene Id: 43740568


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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