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#96585
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For Research Use Only. Not for Use in Diagnostic Procedures.
Applications:
W, IF-F, IF-IC
Reactivity:
H M R
Sensitivity:
Endogenous
MW (kDa):
28
Source/Isotype:
Rabbit IgG
UniProt ID:
#P56177
Entrez-Gene Id:
1745
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Frozen) | 1:200 - 1:800 |
| Immunofluorescence (Immunocytochemistry) | 1:400 - 1:1600 |
Storage
Specificity/Sensitivity
DLX1 (E4T1L) Rabbit mAb recognizes endogenous levels of total DLX1 protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His245 of human DLX1 protein.
Background
Homeobox protein DLX-1 (DLX1) is a member of a family of homeobox genes related to the Drosophila distal-less gene. DLX1 is a transcription factor found in the forebrain of the developing mouse embryo, where it contributes to craniofacial development (1-3). DLX1 also plays a critical role in GABAergic neurogenesis and retinal development (4-7). The DNA-binding activity of DLX1 is mediated by its homeodomain, and DLX1 has been shown to bind to genes that promote neuronal migration and repress neurite growth (8,9). DLX1 expression is regulated by various non-coding RNAs in different cancer types (10-12).
Background References
- Stock, D.W. et al. (1996) Proc Natl Acad Sci USA 93, 10858-63.
- Price, M. et al. (1991) Nature 351, 748-51.
- Qiu, M. et al. (1997) Dev Biol 185, 165-84.
- Anderson, S.A. et al. (1997) Science 278, 474-6.
- Bulfone, A. et al. (1998) Neuron 21, 1273-82.
- He, W. et al. (2001) J Neurosci 21, 8854-62.
- de Melo, J. et al. (2005) Development 132, 311-22.
- Le, T.N. et al. (2007) J Biol Chem 282, 19071-81.
- Cobos, I. et al. (2007) Neuron 54, 873-88.
- Wang, J. et al. (2021) BMC Urol 21, 40.
- Li, Q. et al. (2021) Andrologia 53, e14230.
- Kuo, F.C. et al. (2022) Cancer Cell Int 22, 396.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
W: Western Blotting IF-F: Immunofluorescence (Frozen)
Cross-Reactivity Key
H: Human M: Mouse R: Rat Hm: Hamster Mk: Monkey Vir: Virus Mi: Mink C: Chicken Dm: D. melanogaster X: Xenopus Z: Zebrafish B: Bovine Dg: Dog Pg: Pig Sc: S. cerevisiae Ce: C. elegans Hr: Horse GP: Guinea Pig Rab: Rabbit G: Goat All: All Species Expected
Trademarks and Patents
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
All other trademarks are the property of their respective owners. Visit cellsignal.com/trademarks for more information.
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