DLX1 (E4T1L) Rabbit mAb #96585
- WB
- IF
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Frozen) | 1:200 - 1:800 |
| Immunofluorescence (Immunocytochemistry) | 1:400 - 1:1600 |
Storage
Protocol
Specificity / Sensitivity
DLX1 (E4T1L) Rabbit mAb recognizes endogenous levels of total DLX1 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His245 of human DLX1 protein.
Background
Homeobox protein DLX-1 (DLX1) is a member of a family of homeobox genes related to the Drosophila distal-less gene. DLX1 is a transcription factor found in the forebrain of the developing mouse embryo, where it contributes to craniofacial development (1-3). DLX1 also plays a critical role in GABAergic neurogenesis and retinal development (4-7). The DNA-binding activity of DLX1 is mediated by its homeodomain, and DLX1 has been shown to bind to genes that promote neuronal migration and repress neurite growth (8,9). DLX1 expression is regulated by various non-coding RNAs in different cancer types (10-12).
- Stock, D.W. et al. (1996) Proc Natl Acad Sci USA 93, 10858-63.
- Price, M. et al. (1991) Nature 351, 748-51.
- Qiu, M. et al. (1997) Dev Biol 185, 165-84.
- Anderson, S.A. et al. (1997) Science 278, 474-6.
- Bulfone, A. et al. (1998) Neuron 21, 1273-82.
- He, W. et al. (2001) J Neurosci 21, 8854-62.
- de Melo, J. et al. (2005) Development 132, 311-22.
- Le, T.N. et al. (2007) J Biol Chem 282, 19071-81.
- Cobos, I. et al. (2007) Neuron 54, 873-88.
- Wang, J. et al. (2021) BMC Urol 21, 40.
- Li, Q. et al. (2021) Andrologia 53, e14230.
- Kuo, F.C. et al. (2022) Cancer Cell Int 22, 396.
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