Ferrostatin-1 #19766
Product Information
Product Usage Information
Storage
Product Description
| Molecular Weight | 262.4 g/mol |
| Purity | >98% |
| Molecular Formula | C15H22N2O2 |
| CAS | 347174-05-4 |
| Solubility | Soluble in DMSO at 100 mg/mL or ethanol at 100 mg/mL. |
Background
Ferrostatin-1 is an antioxidant that is a potent, selective inhibitor of erastin-induced ferroptosis with an EC50 value of 60 nM (1,2). It effectively inhibits ferroptosis in cancer cells and prevents glutamate-induced cell death in rat hippocampal brain slices. In disease models, it has been shown to inhibit production of reactive oxygen species (ROS) and depletion of membrane lipids (1). Ferrostatin-1 has been shown to inhibit cell death in cell models of Huntington’s disease, periventricular leukomalacia, and kidney dysfunction (1,2).
Limited Uses
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