NLRP6 (F8J8R) Rabbit mAb #23077
- WB
- IP
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 97 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse NLRP6 protein.
Background
NLR family pyrin domain containing 6 (NLRP6, NALP6, PYPAF5), a member of the NOD-like receptor (NLR) family, acts as an innate immune sensor of microbe-associated molecular patterns (1). NLRP6 is primarily expressed in epithelial cells, mainly in the gastrointestinal tract (1,2,5). Like other NLR family members, NLRP6 is composed of three domains: a pyrin domain (PYD), a nucleotide-binding domain (NBD), and a leucine-rich repeat (LRR) domain (5). Upon activation, NLRP6 may form an inflammasome, a multiprotein complex that functions as a sensor of damage-associated molecular patterns (1-5). The NLRP6 inflammasome is involved in the activation of caspase-1 and subsequent processing of pro-inflammatory cytokines IL-1β and IL-18 as part of the innate immune response (1-5). NLRP6 may also play a role in regulating intestinal homeostasis (2-5).
Limited Uses
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