hnRNP L Antibody #37562
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60, 66 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
hnRNP L Antibody recognizes endogenous levels of total hnRNP L protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His313 of human hnRNP L protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Heterogeneous nuclear ribonucleoprotein L (hnRNP L) belongs to a family of RNA binding multiprotein complexes (hnRNP proteins) that facilitate pre-mRNA processing and transport of mRNA from the nucleus to cytoplasm (1-3). hnRNP L binds to CA repeat elements to regulate splicing and RNA stability (4-6). Binding of hnRNP L has been shown to occur in response to stress stimuli to regulate conformational change and subsequent translation of mRNAs (7). hnRNPL can promote apoptosis by enhancing translation of p53 mRNA (8) . In the context of tumor progression, hnRNPL has been shown to bind and modify translation of critical regulators of cell cycle and apoptosis (9,10).
Limited Uses
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