FcγRIIA (E3K8U) Rabbit mAb #60432
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 40-50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
FcγRIIA (E3K8U) Rabbit mAb recognizes endogenous levels of total FcγRIIA protein. This antibody does not cross-react with FcγRIIB protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro170 of human FcγRIIA protein.
Background
FcγRIIA (CD32A) is a low affinity, IgG Fc-binding receptor belonging to the immunoglobulin receptor superfamily (1-3). In humans, it is expressed on myeloid cells, dendritic cells, and platelets (2-4). FcγRIIA is an activating-type Fc receptor, and signals through an immunoreceptor tyrosine-based activation motif (ITAM) present on its own IgG binding chain (2-4). ITAM signaling is essential for FcγRIIA-dependent phagocytosis and the induction of cytokine secretion (3). In addition to binding to IgG, FcγRI and FcγRII also bind to pentraxin proteins of the innate immune system (5).
Limited Uses
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