Santacruzamate A (CAY10683) #69552
Product Information
Product Usage Information
Santacruzamate A (CAY10683) is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.19 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 278.4 g/mol |
| Purity | >98% |
| Molecular Formula | C15H22N2O3 |
| CAS | 1477949-42-0 |
| Solubility | Soluble in DMSO at 25 mg/ml or ethanol at 20 mg/ml. |
Background
Santacruzamate A (CAY10683) is a cytotoxin isolated from the Panamanian marine cyanobacterium cf. Symploca sp., and is a highly selective inhibitor of histone deacetylases (HDACs), specifically HDAC2 (IC50 = 0.119 nM) and HDAC6 (IC50 = 434 nM) (1). This small molecule has been shown to induce apoptosis via transcriptional inhibition of HDAC2, resulting in an increase of p21 Waf1/Cip1 and p19INK4d expression when combined with an HDAC1 inhibitor (2). Santacruzamate A (CAY10683) has also demonstrated the ability to attenuate amyloid-β protein (Aβ) fragment (Aβ25-35)-induced toxicity through enhancing endoplasmic reticulum (ER) stress tolerance in mice (3). Additionally, HDAC2 has been recognized as a host immune response to the influenza A virus (IVA) and several other viruses, making HDAC inhibitors important compounds to study in relation to viral diseases (4,5).
Limited Uses
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