Ivermectin #72997
Product Information
Product Usage Information
Ivermectin is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 10 mg of powder in 1.14 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 875.1 g/mol |
| Purity | >98%, contains up to 10% B1b form. |
| Molecular Formula | C48H74O14 (B1a form) |
| CAS | 70288-86-7 |
| Solubility | Soluble in DMSO at 70 mg/ml or ethanol at 25 mg/ml. |
Background
Ivermectin is a positive allosteric modulator of the ATP-activated ion channel, P2X purinoceptor 4 (P2X4), as well as the α7 neuronal nicotinic acetylcholine receptor (α7-nAChR) (1,2). The α7-nAChR is required for the cytokine suppressing mechanism of the inflammatory reflex and it stimulates activation of calcium ion transport. Impairment of the α7-nAChR can lead to overproduction of cytokines and a heightened inflammatory response (3). Ivermectin is a known anthelmintic agent, activating the glutamate-gated chloride channels in the nerves and muscles of parasites. The disruption of the parasite’s ingestive activity eventually leads to starvation (4). Ivermectin has been shown to inhibit SARS-CoV-2 replication in vitro with an IC50 value of ~2 μM (5).
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.