Human FGF-7 Recombinant Protein #90162
Product Information
Storage
Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Product Description
| MW (kDa) | 19.0 |
| Purity | A greater than or equal to 90% purity was determined by SDS-PAGE. |
| Endotoxin | Endotoxin levels are less than or equal to 1 EU / 1 μg hFGF-7. |
| Activity | The bioactivity of recombinant hFGF-7 was determined in a 4MBr-5 cell proliferation assay. The ED50 of each lot is less than or equal to 60 ng/mL. |
Source / Purification
Recombinant human FGF-7 was expressed in E. coli and is supplied in a lyophilized form.
Background
FGF-7, or keratinocyte growth factor (KGF), is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-7 binds to receptor FGFR2 IIIb isoform which is also known as KGF receptor (KGFR) (1). FGF-7 functions as a signaling molecule that is involved in many important processes (2,3). FGF-7 helps to repair injured epithelium and is strongly upregulated in dermal fibroblasts after skin injury (4). In addition, animal models of recombinant human FGF-7 have been shown to enhance the regenerative capacity of epithelial cells and protect them from toxic exposure (5).
Limited Uses
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