Selumetinib (AZD6244) #38484
Product Information
Product Usage Information
Selumetinib (AZD6244) is supplied as a lyophilized powder. For an 18 mM stock, reconstitute 10 mg of powder in 1.21 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 457.7 g/mol |
| Purity | >98% |
| Molecular Formula | C17H15BrCIFN4O3 |
| CAS | 606143-53-6 |
| Solubility | Soluble in DMSO at 9 mg/ml. |
Background
Selumetinib (AZD6244), also known as ARRY-142886, is a highly potent and selective non-ATP competitive inhibitor of MEK with an IC50 of 14 nM (1). Researchers have shown this small molecule to inhibit growth in cell lines containing B-Raf and Ras mutations with no effect on normal fibroblasts (1). Treatment with Selumetinib (AZD6244) induces apoptosis and differentiation in tumors from cells with B-Raf or K-Ras mutations (2).
Limited Uses
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