APOBEC3G (D9C6Z) Rabbit mAb #43584
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 40 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
APOBEC3G (D9C6Z) Rabbit mAb recognizes endogenous levels of total APOBEC3G protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly255 of human APOBEC3G protein.
Background
APOBEC3G, a single-strand DNA deaminase that converts deoxycytidine to deoxyuridine (1-3), is a cellular restriction factor blocking the replication of retroviruses (3). It suppresses the replication of human immunodeficiency virus-1 (HIV-1) in T-cells by being packaged into progeny virions and deaminating cytosine to uracil in the nascent minus-strand viral DNA, leading to the accumulation of mutations in the viral genome (1-4). The HIV-1 virion infectivity factor (Vif) inhibits APOBEC3G activity by preventing its incorporation into progeny virions (4,5). In addition, Vif targets APOBEC3G for ubiquitination and subsequent degradation (5).
Limited Uses
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