Cav2.3/CACNA1E Antibody #42437
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 257 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1039 of mouse Cav2.3 protein. Antibodies are purified by peptide affinity chromatography.
Background
Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells. VSCCs are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 is encoded by the CACNA1E gene (1,2). In the brain, Cav2.3 has been implicated in synaptic plasticity (3,4). Interestingly, Cav2.3 may contribute to some neurodegenerative diseases like Parkinson’s disease (5).
Limited Uses
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