PYURF (F9F4X) Rabbit mAb #16847
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 13 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
PYURF (F9F4X) Rabbit mAb recognizes endogenous levels of total PYURF protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala71 of human PYURF protein.
Background
PIGY upstream open reading frame (PYURF) is a mitochondrial S-adenosylmethionine-dependent methyltransferase chaperone. This protein supports the assembly of complex I in the electron transport chain and coenzyme Q biosynthesis (1). In addition, PYURF was also shown to be required for oxidative phosphorylation. Disruption of PYURF gene expression results in isolated complex I deficiency (2). Furthermore, PYURF is suggested to be a potential subunit of the NDUFAF5 hydroxylase complex (3).
Limited Uses
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