SMN1 (F9B6P) Rabbit mAb #74905
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 35 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
SMN1 (F9B6P) Rabbit mAb recognizes endogenous levels of total SMN1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro70 of human SMN1 protein.
Background
The survival motor neuron 1 (SMN1) protein is ubiquitously expressed in mammals (1). SMN1 impacts various aspects of RNA metabolism; it is required for biogenesis of small nuclear ribonucleoprotein (snRNP) particles critical for pre-mRNA splicing. Furthermore, SMN1 is needed for stress granule formation, is found in ribonucleoprotein (RNP) granules moving through neuronal processes, and is part of RNP complexes implicated in synaptic local translation (2,3). Mutations in its coding gene, SMN1, are linked to neuromuscular disease spinal muscular atrophy (SMA), a leading genetic cause of infant mortality (1-4).
Limited Uses
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