Semaphorin 3B (D5A2P) Rabbit mAb #13299
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Semaphorin 3B functions as a tumor suppressor, as research studies have shown that it is deleted or inactivated in lung and breast cancer (10,11). Overexpression of semaphorin 3B inhibits tumor cell proliferation and causes apoptosis (12,13). Semaphorin 3B also inhibits angiogenesis (14). Semaphorin 3B loses its activity upon cleavage by furin-like pro-protein convertases (14).
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- Kruger, R.P. et al. (2005) Nat Rev Mol Cell Biol 6, 789-800.
- Staton, C.A. (2011) Biochem Soc Trans 39, 1565-70.
- Ghanem, R.C. et al. (2011) Curr Eye Res 36, 989-96.
- Nakagawa, Y. et al. (2011) J Immunol 186, 2881-8.
- Suzuki, K. et al. (2008) Nat Immunol 9, 17-23.
- He, Z. and Tessier-Lavigne, M. (1997) Cell 90, 739-51.
- Kolodkin, A.L. et al. (1997) Cell 90, 753-62.
- Chen, H. et al. (1997) Neuron 19, 547-59.
- Tomizawa, Y. et al. (2001) Proc Natl Acad Sci U S A 98, 13954-9.
- Nasarre, P. et al. (2005) Med Sci (Paris) 21, 641-7.
- Tse, C. et al. (2002) Cancer Res 62, 542-6.
- Castro-Rivera, E. et al. (2004) Proc Natl Acad Sci U S A 101, 11432-7.
- Varshavsky, A. et al. (2008) Cancer Res 68, 6922-31.
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