SAM Protein Domain
The SAM domain from the EphA4 receptor.
Domain Binding and Function
The approximately 70 amino acid SAM (Sterile α Motif) domain has been identified from over 400 different proteins responsible for diverse cellular functions in organisms from yeast to man. SAM domains are implicated in mediating protein-protein interactions by forming homo- and heterotypic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain unclear.
Structure Reference
- Stapleton, D. et al. (1999) Nat. Struct. Biol. 6(1), 44–49.
Examples of Domain Proteins
Binding Examples
SAM Domain Proteins | Binding Partners |
Polycomb group chromatin remodeling proteins: |
|
Scm | Homotypic and heterotypic interactions |
Ph | Homotypic and heterotypic interactions |
Rae 28 | Homotypic and heterotypic interactions |
Ste11 Yeast MAPKKK | Ste50 |
Tel ETS Family Transcription Factor | Tel |