WW Protein Domain
WW domain of Pin1 bound to a doubly phosphorylated peptide.
Domain Binding and Function
WW domains are small, 38 to 40 amino acid residue modules implicated in binding to Pro-rich sequences. WW domains and SH3 domains can potentially bind overlapping sites. In addition, the Pin1 WW domain functions as a phosphoserine or phosphothreonine binding module, suggesting that certain WW domains have evolved an alternate mode of action. WW domains bind peptide ligands with dissociation constants in the µM range.
Structure Reference
- Verdecia, M.A. et al. (2000) Nat. Struc. Biol. 7(8) 639–643.
Examples of Domain Proteins
Binding Examples
WW Domain Proteins | Binding Partners | WW Domain Binding Sites |
Yes-Associated Protein (YAP) | Yes, Src-like Tyrosine Kinase | PPPPY |
Nedd4 E3 Ubiquitin Ligase | ΒENaC amiloride-E3 ubiquitin ligase-sensitive epithelial Na+ channel | PPPNY |
FBP – 11 | Formin | PPLP |