The CUT&RUN assay is used to analyze DNA-protein interactions in the genome. This comprehensive protocol video includes a step-by-step demonstration of the CUT&RUN Protocol using the CUT&RUN Assay kit (#86652) from Cell Signaling Technology, and expert advice on experimental advice and tips for success. The CST CUT&RUN Assay Kit can be paired with the DNA Library Prep kit (separate product and protocol) for analysis by NGS.