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Render Timestamp: 2025-01-22T14:08:51.708Z
Commit: da7e4f2f0d1aed1f1f8e20e4e2ecab8f33cbd595
XML generation date: 2024-04-05 20:23:38.908
Product last modified at: 2024-05-30T07:07:19.389Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Mannose Receptor Antibody #12981

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Filter:
  • WB
Western Blotting Image 1: Mannose Receptor Antibody
Western blot analysis of extracts from various cell lines using Mannose Receptor Antibody (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
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Inquiry Info. # 12981

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Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 190
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Mannose Receptor Antibody recognizes endogenous levels of total mannose receptor protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human mannose receptor protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The mannose receptor (MR/CLEC13D/CD206/MMR/MRC1/Macrophage mannose receptor 1) is an endocytic receptor expressed by populations of dendritic cells, macrophages, and nonvascular endothelium (1). The mannose receptor is a heavily glycosylated type I transmembrane protein with three types of extracellular domains and a short carboxy-terminal cytoplasmic domain with no apparent signaling motif (2-4). The extracellular portion of the protein is made up of a CR domain, which binds sulfated glycans, an FNII domain, which binds collagens, and eight C-type lectin domains, which bind carbohydrates containing mannose, fucose, or GlcNAc (4-7). The receptor recycles between the plasma membrane and early endosomes (8). Functions include a role in antigen cross-presentation, clearance of endogenous proteins, pathogen detection, and trafficking through lymphatic vessels (9-12).
For Research Use Only. Not For Use In Diagnostic Procedures.
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