Name: HYOU1 Antibody
Price: 302.00 USD
Availability: InStock

Filter:

WB

Supporting Data

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	150
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

HYOU1 Antibody recognizes endogenous levels of total HYOU1 protein. This antibody reacts weakly with murine and rat HYOU1.

Species Reactivity:

Human, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human HYOU1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Hypoxia up-regulated protein 1 (HYOU1, ORP150) is an endoplasmic reticulum (ER)-resident stress protein whose expression is upregulated in response to a variety of environmental conditions that promote ER stress (1,2). The amino-terminal region of HYOU1 displays extensive similarity to the ATPase domain of HSP70 family proteins, suggesting that HYOU1 contributes to maintaining proper protein folding and secretion under conditions that promote ER stress (2). Research studies have demonstrated that HYOU1 is cytoprotective and is involved in the inhibition of hypoxia-induced cell death (3).

Database Links

UniProt ID: Q9Y4L1

Entrez-Gene Id: 10525

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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HYOU1 Antibody #13452