Dexamethasone #14776
Product Information
Product Usage Information
Dexamethasone is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1.27 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1,000 nM for 1-24 hr.
Storage
Product Description
| Molecular Weight | 392.5 g/mol |
| Purity | >98% |
| Molecular Formula | C22H29FO5 |
| CAS | 50-02-2 |
| Solubility | Soluble in DMSO at 40mg/ml. |
Background
Dexamethasone is a synthetic glucocorticoid that binds to the human glucocorticoid receptor (GR). Treatment of cells with dexamethasone leads to nuclear translocation and activation of GR. This elicits anti-inflammatory, cellular proliferation, and metabolic responses via GR-mediated transcriptional activation or repression of target genes (1-4). Research studies show that dexamethasone inhibits dendritic cell differentiation and maturation (5). The inhibition of nitric oxide synthase by dexamethasone has also been observed (6).
- Wang, Z. et al. (2002) J Biol Chem 277, 26573-80.
- Matthews, L. et al. (2009) Endocrinology 150, 75-86.
- Cole, T.J. (2006) Biotechnol Annu Rev 12, 269-300.
- Beck, I.M. et al. (2009) Endocr Rev 30, 830-82.
- Matasić, R. et al. (1999) J Leukoc Biol 66, 909-14.
- Moncada, S. and Palmer, R.M. (1991) Trends Pharmacol Sci 12, 130-1.
Limited Uses
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