Cripto Antibody #2020
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 18, 20 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Cripto is an important modulator of embryogenesis and oncogenesis (4). It is highly expressed in early embryos, and in embryonic stem (ES) cells where it is involved in cardiomyocytic differentiation and acts as a negative regulator of neurogenesis (5-7). Transient activation of Cripto is essential for the capacity of stem cell self-renewal and pluripotency in ES cells, and in some adult derived stem cells (8). Signaling through Cripto can also stimulate other activities that promote tumorigenesis such as stimulation of proliferation, cell motility, invasion, angiogenesis and epithelial-mesenchymal transition (EMT) (9-11). Cripto is highly expressed in a broad range of tumors, where it acts as a potent oncogene.
- Minchiotti, G. et al. (2000) Mech Dev 90, 133-42.
- Schiffer, S.G. et al. (2001) J Biol Chem 276, 37769-78.
- Yan, Y.T. et al. (2002) Mol Cell Biol 22, 4439-49.
- Strizzi, L. et al. (2005) Oncogene 24, 5731-41.
- Xu, C. et al. (1998) Dev Biol 196, 237-47.
- Parisi, S. et al. (2003) J Cell Biol 163, 303-14.
- Minchiotti, G. (2005) Oncogene 24, 5668-75.
- Beachy, P.A. et al. (2004) Nature 432, 324-31.
- Wechselberger, C. et al. (2001) Exp Cell Res 266, 95-105.
- Bianco, C. et al. (2005) J Natl Cancer Inst 97, 132-41.
- Strizzi, L. et al. (2004) J Cell Physiol 201, 266-76.
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