CELA2A (E1D6G) Rabbit mAb #23050
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 26 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
CELA2A (E1D6G) Rabbit mAb recognizes endogenous levels of total CELA2A protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly176 of human CELA2A protein.
Background
Chymotrypsin-like elastase family member 2A (CELA2A) was initially described as an exocrine elastase, produced by exocrine cells of the mammalian pancreas (1,2). Deeper examination revealed additional, lower levels of CELA2A expression by a small subset of pancreatic islet cells and many other tissues, including the adrenal glands, intestine and colon, liver, and white adipose tissue (3). Notably, gene expression datasets have reported aberrant CELA2A expression by other tissues in association with specific disease states (e.g., insulin resistance or Type II diabetes) (3), while increased expression of CELA2A by colonic epithelial cells was reported in patients with inflammatory bowel diseases (4). CELA2A is a secreted protease; in normal physiology, it is released into circulation following an elevation in plasma glucose levels, where it promotes both insulin secretion and degradation, leading to increased insulin sensitivity (3). Importantly, mutations in the CELA2A gene were shown to inhibit the ability of CELA2A to regulate insulin dynamics (3). Collectively, these studies suggest that CELA2A may be an attractive therapeutic target in both metabolic and inflammatory diseases.
Limited Uses
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