Name: GIGYF2 Antibody
Price: 302.00 USD
Availability: InStock

Filter:

WB
IP

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	180
SOURCE	Rabbit

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

GIGYF2 Antibody recognizes endogenous levels of total GIGYF2 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu355 of human GIGYF2 protein. Antibodies are purified by peptide affinity chromatography.

Background

GRB10-interacting GYF protein 2 (GIGYF2) is part of a macromolecular protein complex, which also also contains 4EHP, that functions to repress the translation of a distinct subset of mRNAs during embryonic development. Indeed, disruption of 4EHP and GIGYF2 complex formation prevents normal embryonic development in mice (1). Research studies have also demonstrated that GIGYF2 is involved in repressing translation of defective mRNAs, which prevents expression of potentially toxic protein products (2). In addition to its role in repression of protein translation, GIGYF2 may cooperate with the Grb10 adapter protein to regulate signaling of receptor tyrosine kinases (3).

Database Links

UniProt ID: Q6Y7W6

Entrez-Gene Id: 26058

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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GIGYF2 Antibody #24120