Render Target: STATIC
Render Timestamp: 2024-11-21T12:55:27.807Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:58:27.697
Product last modified at: 2024-11-01T19:45:08.213Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

GIGYF2 (E7F7I) Rabbit mAb #31638

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 180
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    GIGYF2 (E7F7I) Rabbit mAb recognizes endogenous levels of total GIGYF2 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1091 of human GIGYF2 protein.

    Background

    Grb10-interacting GYF protein 2 (GIGYF2) is part of a macromolecular protein complex, which also contains 4EHP, that functions to repress the translation of a distinct subset of mRNAs during embryonic development. Indeed, disruption of 4EHP and GIGYF2 complex formation prevents normal embryonic development in mice (1). Research studies have also demonstrated that GIGYF2 is involved in repressing translation of defective mRNAs, which prevents expression of potentially toxic protein products (2). In addition to its role in repression of protein translation, GIGYF2 may cooperate with the Grb10 adapter protein to regulate signaling of receptor tyrosine kinases (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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