Render Target: STATIC
Render Timestamp: 2025-01-27T11:49:00.122Z
Commit: 8d9f38232df81570bbc23eaa560b31cb39dd8776
XML generation date: 2024-11-18 16:03:16.642
Product last modified at: 2025-01-01T09:03:45.713Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

AUTS2 (F3U1I) Rabbit mAb #40506

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 180, 80-90
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    AUTS2 (F3U1I) Rabbit mAb recognizes endogenous levels of total AUTS2 protein, including both long and short isoforms.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly776 of human AUTS2 protein.

    Background

    Autism susceptibility candidate 2 (AUTS2) is a transcriptional activator protein that was first identified in a pair of homozygous twins with autism spectrum disorder (ASD) (1). AUTS2 associates with the non-canonical polycomb repressive complex 1 (ncPRC1) and recruits the histone acetyltransferase p300 to activate gene expression (2). AUTS2 is primarily expressed in early developing brain tissue and contributes to neuronal differentiation (3). AUTS2 is expressed as either a full-length “long” protein isoform or a “short” isoform lacking the N-terminus due to an alternative transcription start site (4). The exact biological differences between the two isoforms are not fully understood, but they may target distinct genes during differentiation (5). Defects in the AUTS2 gene result in AUTS2 syndrome, a neurodevelopmental disorder characterized by intellectual disability, microcephaly, and autistic traits (6-8). 
    For Research Use Only. Not For Use In Diagnostic Procedures.
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