CD109 (E8L2W) Rabbit mAb (Alexa Fluor® 488 Conjugate) #50165
- F
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | |
Source/Isotype | Rabbit IgG |
Application Key:
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
Product Usage Information
Application | Dilution |
---|---|
Flow Cytometry (Live) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly653 of human CD109 protein.
Background
CD109 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein that belongs to the alpha2-macroglobulin family of thioester containing proteins (1). CD109 is associated with TGF-beta receptor I (TbRI) and inhibits TGF-beta signaling (2,3). Cleavage of CD109 at its Furin cleavage site results in the release of its large amino-terminal domain, which then binds to the TGF-beta receptor I to inhibit TGF-beta signaling (4-7). CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors (8-10). Elevated CD109 expression has been considered a diagnostic/prognostic marker for several types of cancers (11-14).
- Lin, M. et al. (2002) Blood 99, 1683-91.
- Finnson, K.W. et al. (2006) FASEB J 20, 1525-7.
- Zhang, J.M. et al. (2015) Biochem Biophys Res Commun 459, 252-8.
- Hagiwara, S. et al. (2010) Oncogene 29, 2181-91.
- Litvinov, I.V. et al. (2011) Exp Dermatol 20, 627-32.
- Zhou, S. et al. (2017) Oncotarget 8, 95632-47.
- Li, C. et al. (2016) Biochem J 473, 537-47.
- Hashimoto, M. et al. (2004) Oncogene 23, 3716-20.
- Sato, T. et al. (2007) Pathol Int 57, 719-24.
- Qi, R. et al. (2018) J Transl Med 16, 88.
- Emori, M. et al. (2015) J Surg Oncol 111, 975-9.
- Jia, W. et al. (2016) Oncotarget 7, 55328-42.
- Yokoyama, M. et al. (2017) Int J Hematol 105, 614-22.
- Chuang, C.H. et al. (2017) Nat Med 23, 291-300.
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.