Render Target: STATIC
Render Timestamp: 2024-11-21T13:19:14.024Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-10-21 12:16:06.217
Product last modified at: 2024-10-23T12:15:15.980Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

IgA (N1CLA) Mouse mAb #50384

Filter:
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    IHC Leica Bond 1:800 - 1:3200
    Immunohistochemistry (Paraffin) 1:400 - 1:1600

    Storage

    Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IgA (N1CLA) Mouse mAb recognizes endogenous levels of IgA protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to 129 amino acids of the heavy chain constant region of human immunoglobulin A molecule.

    Background

    Immunoglobulin A (IgA) is one of the five major human immunoglobulin isotypes and the most abundant immunoglobulin in the mucosal immune system. The structure of IgA consists of two identical heavy chains and two identical light chains, linked by disulfide bonds. Human IgA exists as two subclasses, IgA1 and IgA2, that are structurally different in the flexible hinge region (1). The secreted form of IgA (SIgA) is the predominant mucosal antibody that contains two copies of IgA, a joining-chain (J chain), and a secretory component (SC) (2). IgA antibodies are expressed by B cells and are a part of both the innate and adaptive immune response (3). Since IgA antibodies are secreted by mucosa, they are important when studying autoimmune diseases associated with the gastrointestinal tract (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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