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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Drebrin (pan) Antibody #5052

Filter:
  • WB
Western Blotting Image 1: Drebrin (pan) Antibody
Western blot analysis of extracts from various cell lines and mouse and rat brain using Drebrin (pan) Antibody (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). Absence of detectable Drebrin expression in A-431 cells is expected.

To Purchase # 5052

Cat. # Size Qty. Price Ships
5052S 100 µl
$306 Jan 22

Supporting Data

REACTIVITY H M R Mk
SENSITIVITY Endogenous
MW (kDa) 110-132
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Mk-Monkey 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Drebrin (pan) Antibody recognizes endogenous levels of total DrebrinE and DrebrinA proteins.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu580 of human Drebrin protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Developmentally-regulated brain proteins (Drebrins) are cytoplasmic proteins that were originally identified in the brain as F-actin-binding proteins. There are two mammalian isoforms: adult type (A) and embryonic type (E). These isoforms are derived from a single gene through alternative RNA splicing mechanisms (1). Drebrin E has been observed to accumulate in the developmental stage of migrating neurons and in the growing cell processes of neurons. Drebrin A is found at the dendritic spines of mature cortical neurons where it plays a role in synaptic plasticity (2,3). Although drebrins are primarily found in neurons, they have also been found in skeletal muscle, heart, pancreas, and kidney. Research studies have shown that reduced expression of drebrin in the brain could be associated with Alzheimer’s Disease, Down Syndrome (4), and bipolar disorders (5).
For Research Use Only. Not For Use In Diagnostic Procedures.
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