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Product last modified at: 2025-01-01T09:03:19.627Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SOX11 (E7G9N) Rabbit mAb #58207

Filter:
  • WB
  • IP
  • F
Western Blotting Image 1: SOX11 (E7G9N) Rabbit mAb
Western blot analysis of extracts from various cell lines using SOX11 (E7G9N) Rabbit mAb (upper) and GAPDH (D16H11) XP® Rabbit mAb #5174 (lower).

To Purchase # 58207

Cat. # Size Qty. Price Ships
58207T 20 µl
$153 Jan 22
58207S 100 µl
$339 Jan 22

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 70
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
  • F-Flow Cytometry 
Species Cross-Reactivity Key:
  • H-Human 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:50
Flow Cytometry (Fixed/Permeabilized) 1:50 - 1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

SOX11 (E7G9N) Rabbit mAb recognizes endogenous levels of total SOX11 protein. In some cell extracts, the antibody weakly detects a 48 kDa protein. The identity of this protein is unknown.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro323 of human SOX11 protein.

Background

SRY-related high mobility group box (SOX) proteins comprise a large family of widely conserved transcription factors that play important roles in development. SOX proteins possess a high mobility group (HMG) motif that binds the DNA minor groove. SOX proteins typically do not mediate transcription directly, but require binding partners that regulate their ability to mediate transcription of target genes that control cell fate determination and development (reviewed in 1). SOX11 is generally described as a neural transcription factor, whose expression is critical for the establishment of neuronal identity in the embryonic mammalian brain (2). It has furthermore been reported to function as a pioneer transcription factor, able to bind nucleosomes and influence the transcription of genes in regions of closed chromatin, in similar fashion to its close relative SOX2 (3). Postnatal expression of SOX11 is reported to be uncommon, but aberrant SOX11 expression has been reported in numerous malignancies, including mantle cell lymphoma, Burkitt's lymphoma, and various lymphoblastic leukemias (4-6).
For Research Use Only. Not For Use In Diagnostic Procedures.
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