Render Target: STATIC
Render Timestamp: 2024-11-21T13:03:36.925Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:58:14.847
Product last modified at: 2024-11-15T18:45:08.828Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SIGMAR2/TMEM97 (E8R4R) Rabbit mAb #62790

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 19
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SIGMAR2/TMEM97 (E8R4R) Rabbit mAb recognizes endogenous levels of total SIGMAR2/TMEM97 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro57 of human SIGMAR2/TMEM97 protein.

    Background

    Sigma intracellular receptor 2 (SIGMAR2 or TMEM97) is an endoplasmic reticulum (ER)-resident membrane chaperone protein that regulates the sterol transporter NPC1 (1). Recently, SIGMAR2/TMEM97 was identified as the opioid 2 receptor. Opioid receptors are a large super family of 7 transmembrane-spanning G protein-coupled receptors (GPCRs) that are activated by both endogenous opioid peptides and by exogenously administered opiate compounds (2). Opioid receptors are of pharmacological interest not only as analgesics but to treat neurological disorders including psychiatric and neurodegenerative diseases. Opioid receptors are classified pharmacologically, including σ1 and σ2 type receptors. Although SIGMAR1 was identified in 1996 as the σ1 receptor, identification of the σ2 type receptor remained elusive until 2017 when TMEM97 was identified as the σ2 type receptor (3,4). In addition to acting as an opioid receptor, SIGMAR2/TMEM97 may also act within a complex to regulate cellular update of Aβ, the pathological hallmark of Alzheimer's disease (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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    KARPAS cell line source: Dr. Abraham Karpas at the University of Cambridge.
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