A-769662 #64839
Product Information
Product Usage Information
A-769662 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 924.9 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Product Description
| Molecular Weight | 360.4 g/mol |
| Purity | >98% |
| Molecular Formula | C20H12N2O3S |
| CAS | 844499-71-4 |
| Solubility | Soluble in DMSO at 30 mg/ml or ethanol at 5 mg/ml with slight warming. |
Background
A-769662 is a potent activator of AMP-activated protein kinase (AMPK) by allosterically binding to the β and γ subunits and by inhibiting dephosphorylation of AMPK on Thr172 (1). This small molecule selectively targets AMPK heterotrimers containing the β1 subunit (2). A-769662 has been shown to stimulate purified rat liver AMPK (EC50 = 0.8 µM) and inhibit fatty acid synthesis in rat hepatocytes (IC50 = 3.2 µM) (3). Treatment of adipocytes with A-769662 inhibits cell differentiation, leads to over-activation of AMPK, and inactivation of acetyl-CoA carboxylase (ACC), making this an interesting compound when studying obesity (4).
Limited Uses
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