Render Target: STATIC
Render Timestamp: 2024-10-25T10:20:28.668Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-30 01:57:31.237
Product last modified at: 2024-09-30T08:02:17.038Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FcγRIV (E8I7C) Rabbit mAb #73741

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 30-40
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FcγRIV (E8I7C) Rabbit mAb recognizes endogenous levels of total mouse FcγRIV protein. This antibody does not cross-react with mouse FcγRIA, FcγRIIA, or FcγRIIB. Non-specific staining was observed in adipose tissue by immunohistochemistry.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with mouse FcγRIV recombinant protein.

    Background

    FcγRIV is an activating Fcγ receptor present in mice but not humans (2). Binding of Fc receptors to IgG, immune complexes, and opsonized particles results in immune cell activation and effector responses (2). FcγRIV is expressed by myeloid cells and binds to IgG2a and IgG2b, but not to IgG1 or IgG3 (1). FcγRIV signals through ITAM-containing FcRγ (2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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