FATP2/SLC27A2 (E8F8O) Rabbit mAb #78771
- WB
- IP
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 70 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val381 of human FATP2/SLC27A2 protein.
Background
Fatty acid transport protein 2 (FATP2), also known as solute carrier family 27 member 2 (SLC27A2), transports long-chain fatty acids into cells at the cell membrane. FATP2/SLC27A2 also functions as a very long-chain acyl-CoA synthetase in the endoplasmic reticulum to activate very long-chain fatty acids (1). Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that accumulate in many diseases. The immunosuppressive activity of PMN-MDSCs is critical in regulating immune responses in cancer. Studies show that FATP2/SLC27A2 expression is upregulated in PMN-MDSCs. FATP2/SLC27A2 mediates the suppressive activity of PMN-MDSCs by increasing the uptake of arachidonic acid and synthesis of prostaglandin E2. In addition, deletion of FATP2/SLC27A2 is shown to abolish the suppressive activity of PMN-MDSCs (2). These results suggest that targeting FATP2/SLC27A2 may increase anti-tumor immunity (2,3).
Limited Uses
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