MAGE-A10 (E9V2Q) Rabbit mAb #81740
- WB
- IP
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 62 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunohistochemistry (Paraffin) | 1:500 - 1:2000 |
Storage
For a carrier free (BSA and azide free) version of this product see product #77478.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Melanoma-associated antigen-A10 (MAGE-A10) is a CTA that belongs to the type I MAGE family of proteins. Unlike other members of the MAGE-A subfamily, MAGE-A10 is a nuclear protein (4). Research studies have shown that MAGE-A10 expression is normally restricted to the human testis and placenta but is aberrantly upregulated in a number of human solid tumors, such as lung cancer, melanoma, bladder cancer, and esophageal carcinoma (4-6). Due to its upregulated expression in human tumors and high degree of immunogenicity, MAGE-A10 has received significant attention as a novel immunotherapy target through the use of vaccines and adoptive cell therapy (7-9).
- Caballero, O.L. and Chen, Y.T. (2009) Cancer Sci 100, 2014-21.
- De Smet, C. et al. (1999) Mol Cell Biol 19, 7327-35.
- Gjerstorff, M.F. et al. (2015) Oncotarget 6, 15772-87.
- Rimoldi, D. et al. (1999) Int J Cancer 82, 901-7.
- Schultz-Thater, E. et al. (2011) Int J Cancer 129, 1137-48.
- Lin, J. et al. (2004) Clin Cancer Res 10, 5708-16.
- Valmori, D. et al. (2001) Cancer Res 61, 509-12.
- Chianese-Bullock, K.A. et al. (2005) J Immunol 174, 3080-6.
- Dutoit, V. et al. (2001) Cancer Res 61, 5850-6.
Limited Uses
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