EphA1 (D6V7I) Rabbit mAb #90673
- WB
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 130 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
The EphA1 receptor preferentially binds ephrin-A1 as a ligand (6). This ligand-receptor interaction stimulates EphA1 signaling and regulates cell morphology and motility through the ILK-RhoA-ROCK pathway (7). The EphA1 gene has been associated with late-onset Alzheimer's diseases (8,9). The role of EphA1 in cancer development falls into two opposite categories. In some type of cancer such as prostate, gastric and liver cancer, high expression of EphA1 associates with cancer metastasis and invasion (10-12). For other types of cancers, such as colon cancer and nonmelanoma skin cancer, downregulation of the protein correlates with cancer development (11,12). The bidirectional signaling modulation of Ephrin-Ephrin receptor interaction might contribute this paradox phenomena (13).
- Wilkinson, D.G. (2000) Int Rev Cytol 196, 177-244.
- Klein, R. (2001) Curr Opin Cell Biol 13, 196-203.
- Dodelet, V.C. and Pasquale, E.B. (2000) Oncogene 19, 5614-9.
- Holder, N. and Klein, R. (1999) Development 126, 2033-44.
- Brückner, K. et al. (1997) Science 275, 1640-3.
- Coulthard, M.G. et al. (2001) Growth Factors 18, 303-17.
- Yamazaki, T. et al. (2009) J Cell Sci 122, 243-55.
- Naj, A.C. et al. (2011) Nat Genet 43, 436-41.
- Hollingworth, P. et al. (2011) Nat Genet 43, 429-35.
- Wang, Y. et al. (2016) J Exp Clin Cancer Res 35, 65.
- Herath, N.I. et al. (2009) Br J Cancer 100, 1095-102.
- Hafner, C. et al. (2006) Mod Pathol 19, 1369-77.
- Pasquale, E.B. (2008) Cell 133, 38-52.
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