TIPE2 (E5Q2S) Rabbit mAb (Alexa Fluor® 488 Conjugate) #95116
- F
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Description
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Fixed/Permeabilized) | 1:50 |
Storage
Protocol
Specificity / Sensitivity
TIPE2 (E5Q2S) Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total TIPE2 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the sequence of human TIPE2 protein, including the carboxy terminus.
Background
Tumor necrosis factor-α (TNF-α)-induced protein 8-like 2 (TIPE2) is a negative regulator of innate and adaptive immunity, and is important in maintaining immune homeostasis. TIPE2 inhibits TGF-β activated kinase 1 (TAK1), a key regulator of inflammatory signaling (1). TIPE2 inhibits oncogenic Ras activity, and deficiency of TIPE2 is associated with resistance to cell death and increased cell migration (2). TIPE2 is downregulated in several human cancers, and may serve as a tumor suppressor and biomarker (3).
Limited Uses
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