Render Target: STATIC
Render Timestamp: 2025-01-23T06:51:49.720Z
Commit: da7e4f2f0d1aed1f1f8e20e4e2ecab8f33cbd595
XML generation date: 2024-09-30 01:58:40.151
Product last modified at: 2025-01-01T09:00:31.085Z
Cell Signaling Technology Logo

Basket Updated

0

Items added

1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CCDC22 (E3F5L) Rabbit mAb #97298

Filter:
  • WB
Western Blotting Image 1: CCDC22 (E3F5L) Rabbit mAb
Western blot analysis of extracts from various human, mouse, and rat cell lines using CCDC22 (E3F5L) Rabbit mAb.

To Purchase # 97298

Cat. # Size Qty. Price
97298T 20 µl
$153
97298S 100 µl
$339

Supporting Data

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa) 72
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

CCDC22 (E3F5L) Rabbit mAb recognizes endogenous levels of total CCDC22 protein.

Species Reactivity:

Human, Mouse, Rat

The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

Species predicted to react based on 100% sequence homology:

Pig

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CCDC22 protein.

Background

Coiled-coil domain-containing protein 22 (CCDC22) is a highly conserved protein that harbors an N-terminal calponin homology-like (NN-CH) domain and a C-terminal coiled-coil domain. CCDC22 is a core subunit of the COMMD/CCDC93/CCDC22 (CCC) protein complex, which also consists of CCDC93 and any one of ten COMMD proteins. The CCC complex, which is a subcomplex of the commander complex, plays a key role in protecting the stability and promoting the endosomal recycling of cell surface transmembrane proteins, such as integrins, LDLR, and the ATP7A copper transporter (1-3). Research studies have also demonstrated that as part of a ubiquitin ligase complex, CCDC22 activates proinflammatory NF-κB signaling by promoting the ubiquitin-dependent degradation of IκB proteins (4).
For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
All other trademarks are the property of their respective owners. Visit our Trademark Information page.