A-769662 #64839

Name: A-769662
Price: 131.00 USD
Availability: InStock

Product Information

Product Usage Information

A-769662 is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 924.9 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

Storage

Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Description

Molecular Weight	360.4 g/mol
Purity	>98%
Molecular Formula	C₂₀H₁₂N₂O₃S
CAS	844499-71-4
Solubility	Soluble in DMSO at 30 mg/ml or ethanol at 5 mg/ml with slight warming.

Background

A-769662 is a potent activator of AMP-activated protein kinase (AMPK) by allosterically binding to the β and γ subunits and by inhibiting dephosphorylation of AMPK on Thr172 (1). This small molecule selectively targets AMPK heterotrimers containing the β1 subunit (2). A-769662 has been shown to stimulate purified rat liver AMPK (EC₅₀ = 0.8 µM) and inhibit fatty acid synthesis in rat hepatocytes (IC₅₀ = 3.2 µM) (3). Treatment of adipocytes with A-769662 inhibits cell differentiation, leads to over-activation of AMPK, and inactivation of acetyl-CoA carboxylase (ACC), making this an interesting compound when studying obesity (4).

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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